The purpose of this study was to determine whether PhNRs (Photopic negative response) recorded with the RETeval system and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) are significantly correlated in eyes with optic nerve disorders. Patients with optic nerve disorders had significantly smaller PhNRs compared to the control subjects and the ROC analysis indicated that both PhNR and cpRNFTLhad comparable diagnostic abilities of detecting optic nerve disorders […].

Authors recommend combining both OCT and PhNR methods to improve the accuracy of the diagnosis of optic nerve disorders. PhNR and retinal nerve fibre thickness are equivalent, but the interpretation of PhNR is easier and more consistent regardless of onset of disease.