Enhance the glaucoma picture Measure ganglion cell function
PhNR testing with the RETeval® is a vital tool for managing patients with glaucoma and other optic nerve diseases with objective assessments of ganglion health.
El diagnóstico precoz es esencial para prevenir la pérdida de visión por un avance en la degeneración de las células ganglionares.
However, glaucoma is often challenging to diagnose and manage. Testing such as perimetry and OCT imaging are standard of care, but are all too often hampered by media opacities (imaging for cup-to-disc-ratio), unspecific testing methods (IOP), or subjective and bothersome to complete (visual field test).
PhNR significa Photopic Negative Response (respuesta fotópica negativa) y es una prueba electrorretinográfica para analizar el funcionamiento de las células ganglionares.
During the Photopic Negative Response test with full-field flash ERG, the retina is illuminated with a red flash on a blue background under light-adapted conditions. This last negative peak is derived from the ganglion cells and their axons and is generally used to evaluate subjects for Glaucoma.
The PhNR response from ERG is described by a time (implicit time) and amplitude. For glaucoma diagnosis and management, several parameters are given as the disease itself is complex [37].
The RETeval PhNR test objectively measures ganglion cells function by evaluating the electrical activity of the cells to a light stimulus. Knowing how the ganglion cells are functioning may assists in detecting and monitoring glaucomatous changes in patients.
La prueba ofrece una alta objetividad y repetibilidad, es independiente de las opacidades de los medios y es adecuada también para pacientes con habilidades motoras y cognitivas reducidas [31][32][34].
Real time pupillography continuously adjusts for pupil size and can be used for patients in any stage of dilation
Our patented, non-invasive Sensor Strip skin electrodes mean that no corneal electrodes are required.
The handheld RETeval device is light, portable, and easy to use. Technicians can be trained in minutes.
Se espera que el dispositivo RETeval detecte los cambios con un alto grado de precisión
Kita et al. have compared seven parameters of the RETeval PhNR test for their ability to differentiate between early or moderate glaucoma from a healthy control group. In this study, high accuracy of the PhNR test was found [38].
(Early glaucoma)
Analyze the PhNR Amplitude at minimum
(Moderate glaucoma)
Analyze the PhNR W-ratio
PhNR testing with the RETeval Device provides sensitive, objective monitoring of retinal changes for more informed follow-up, even where no changes in visual field or RNFL could be detected
Hui et al. detectaron mejoras en la función interna de la retina tras el tratamiento con nicotinamida, cuando no se habían observado mejoras en el campo visual o en el RNFL [39].
Our new algorithm provides a significant improvement in test/retest variability, leading to improved ability to track patient progress longitudinally. Additionally, the reference range is narrower, leading to an enhanced ability to aid in the detection of abnormal ganglion cell function.
El protocolo es compatible con ISCEV*, utiliza los ajustes de estímulos más eficaces y está disponible en diferentes configuraciones que permiten a los médicos ajustarse según las condiciones del paciente (opciones de prueba corta y larga, midriática y no midriática).
*Sociedad Internacional de Electrofisiología Clínica de la Visión
El informe de la prueba PhNR indica la amplitud y el tiempo implícito de las dos primeras ondas.
The typical PhNR values such as amplitude and implicit time at the minimum are shown below the curves. For the support of a differential glaucoma diagnosis and management, other parameters have been analyzed by researchers, such as the W-ratio, which is calculated from the PhNR, a-, and b-wave amplitudes.
Our updated PhNR reports put all the criteria you need to consider dysfunction front and center, allowing you to make better clinical calls for your patients while saving valuable time.
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Warning: This product can expose you to chemicals including lead, which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Substance Tables:
The table below lists substances which may be contained within LKC’s RETeval and RETevet products. Substances listed as Type 1 are within permissible levels in one or more of LKC’s products. Substances listed as Type 2 are used in the production of some components used in LKC products and may be present at trace levels, but are typically destroyed during processing.
RETeval and RETevet Devices
| Substance | CAS # | Type | Listed as causing: |
| Nickel | 7440-02-0 | 1 | Cancer |
| Acrylonitrile | 107-13-1 | 2 | |
| Ethylbenzine | 100-41-4 | 2 | |
| Crystaline Silica | 14808-60-7 | 1 | |
| Lead | 7439-92-1 | 1 | Cancer Developmental Toxicity Male Reproductive Toxicity Female Reproductive Toxicity |
| Methylene Chloride | 75-09-2 | 2 | Cancer Female Reproductive Toxicity |
| Bisphenol A | 80-05-7 | 2 | |
| N-Hexane | 110-54-3 | 2 | Male Reproductive Toxicity |