Case study
ERG Provides Confidence to Monitor or Treat
by Nate Lighthizer, OD, FAAO
Patient History
A 32-year-old female was referred to our clinic for additional testing. She was diagnosed with glaucoma five years prior, at a very young age, and had been using a prostaglandin analog for most of that time. At the visit, she disclosed that she is a realtor and was tired of her clients commenting on her red eyes. As a result, she had stopped taking her medication 5 months prior. Her records revealed that there was no increase in her IOP since stopping the medication. At the current visit IOP was 13 mm Hg OD and 13 mm Hg OS. Central corneal thickness was slightly thinner than normal at 535 OD and 530 OS.
The fundus exam showed a .75 cup to disc ratio in the right eye and an .85 to .9 cup to disc ratio in the left eye (Figure 1). The discs also appeared slightly larger than normal, which raised my concern. I wanted to learn whether this patient truly has glaucoma or if she has physiologic cupping.
When we performed an OCT (Figure 2), the ganglion cell structure and retinal nerve fiber layer (RNFL) in the right and left eye were both flagged. The average RNFL thickness was 64 OD and 61 OS, which is very concerning and not what we would expect to see in a patient this age. However, the visual field looked pretty good (Figure 3).
Figure 1: Fundus Photos Figure 2: OCT Figure 3: Visual Field
Why Was the ERG Test Performed?
The outstanding visual field presented us with a diagnostic conundrum. Consider that mild glaucoma, by definition, has no visual field defects. We recognized that the patient may have pre-parametric glaucoma, meaning she has structural changes before parametric visual field defects. However, the degree of damage on the OCT was too alarming to disregard without further investigation. The ERG was crucial to help break the tie between the structural tests and the subjective, functional visual field.
What Were the ERG Findings?
When reviewing results of the PhNR test, the higher the W-ratio the better. If the patient scored 11% or less on the W-ratio, it would be concerning, but her scores far exceeded these values, which indicates that her ganglion cells are functioning well. Notably, the B-wave implicit time is flagged in this case, meaning it warrants further investigation and can be indicative of optic nerve dysfunction. However, having already performed a trifecta of testing (OCT, VF, and ERG), we can be confident that the B-wave is an artifact of the large cupping and structural anomalies that led to concern in the first place, whereas the W-ratio confirms what we saw on the visual field.
Figure 4: ERG
How Did the ERG Impact Next Steps?
Thanks to the ERG, we were able to conclude that this is a classic case of red disease and not necessarily true pathology. Rather, the large cups and discs complicate the OCT findings and are reflected in the B-wave. In fact, the disparity between the B-wave and the W-ratio further confirms the red disease. As a result, we can safely monitor this patient closely without treatment. I would not have felt comfortable making that choice without the ERG.
Why We Use RETeval
I began using ERG technology during my residency and later, in 2010, the Oklahoma College of Optometry invited me to take over as the chief of electrodiagnostics. In 2023, we acquired our first RETeval device and we love it because it provides objective functional data that we can take right to the patient. In just a few short minutes, you can obtain objective functional data for both eyes, which helps us diagnose disease sooner and follow patients with greater confidence.
Practice Protocol
We use the photopic negative response (PhNR) protocol in our glaucoma patients to help test ganglion cell function because it gives us so much more confidence in our clinical decision-making. I believe an ERG should be performed on any patient that has ocular pathology where we need functional information. Specifically, we perform ERG on patients who have:
- Any degree of structural change
- Uncontrolled disease
- Vision changes
- Diabetes for longer than 5 years
Nate Lighthizer, OD, FAAO
Northeastern State University (Tahlequah, OK)
Dr. Lighthizer serves in multiple roles as a faculty member of the Oklahoma College of Optometry, including Chief of the Electrodiagnostics Clinic, Director of Continuing Education, and founder and head of the Dry Eye Clinic. He is a founding member of the Intrepid Eye Society, a group of emerging thought leaders in optometry, and currently serves as Vice President. Dr. Lighthizer is a nationally recognized speaker on topics such as advanced ophthalmic procedures, ocular disease, and electrodiagnostics.