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Special Dinner Presentation

Meaningful Clinical Endpoints with ERG

Originally presented at a dinner event at ARVO 2022 entitled: “Meaningful Clinical Endpoints with ERG: Why Detecting Functional Change before Structural Change Matters”

The talk centered on the handheld and non-mydriatic RETeval Device for ERG testing that is rapid and non-invasive. ERG testing is an established biomarker to track both safety and efficacy endpoints for pharmaceutical or clinical research in the ocular space. The RETeval Device is therefore the ideal tool for conducting these types of studies.

Dr. Mitch Brigell, PhD presented on practical electroretinographic testing with the RETeval as both a clinical efficacy and a translational biomarker. It provides, for example, a functional measure of diabetic retinopathy risk progression that was more predictive than structural imaging. Likewise, functional testing of the ganglion cell layer (PhNR) provides an objecting measure of glaucoma.

Dr. Quentin Davis, PhD, presented on the scientific and logistical rationale for conducting clinical trials with ERG testing using the RETeval Device. The reliability and relatively inexpensive cost of the unit, combined with it’s rapid and non-invasive interface makes it ideal for safety and efficacy endpoint tracking in clinical trials related to ocular disease.

Presented By:

Quentin Davis, PhD

Quentin Davis
About Dr. Davis

Quentin is Vice President of Operations and Development responsible for the technical aspects for the company’s UTAS and RETeval products. We often refer to him as the brains behind this transformational RETeval ERG device.

Quentin was previously involved in immunoassay, biological warfare detection, and in vitro diagnostic device development for 13 years before joining LKC in 2010. He was the project lead for the M1R electrochemiluminescence reader for IGEN International, the Head of Intellectual Property and Engineering Manager for BioVeris Corporation where he also served as mechanical lead for their M1M project. Prior to joining LKC, Quentin was the Engineering manager for Wellstat Diagnostics, where he was designing an in vitro diagnostic device. He is a registered U.S. Patent Agent and is an inventor on 18 U.S. patent applications.

Quentin holds BS, MS, and Ph.D. degrees from the Massachusetts Institute of Technology in Electrical Engineering and Computer Science. Quentin lives in Urbana, Maryland and spends his free time with his wife and four children, including twins! He engages his kids with household science projects ranging from solar balloons and icicle makers to windmills and hydroelectric power plants.

Mitch Brigell, PhD

Dr. Mitch Brigell, MD, PhD
About Dr. Brigell

Interested in using the RETeval® Device to power your research?

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Dr. Mitch Brigell, MD, PhD

Dr. Mitch Brigell, MD, PhD

Mitchell Brigell occupies the position of Head-Clinical Development & Strategy at Ocuphire Pharma, Inc. Additionally, he formerly held the position of Vice President-Clinical Development at Aerpio Therapeutics, Inc. as well as Executive Director of Translational Medicine, Ophthalmology at Novartis Institutes of BioMedical Research. He also held roles of increasing responsibility at Parke-Davis/Pfizer in Experimental Medicine and Clinical Technologies. He originally joined the pharmaceutical industry as part of the Clinical Development team for Pregabalin (Lyrica). Dr. Brigell spent over a decade in academic medicine at Loyola University and the University of Chicago in the Departments of Neurology, Neuroscience, and Ophthalmology. His area of academic interest focused on electrophysiological and behavioral effects of diseases of the retina and optic nerve. He has published over 70 scientific papers, is a Fellow of the Association of Research in Vision and Ophthalmology, and is the Vice-President of the Americas for the International Society for Clinical Electrophysiology of Vision. Dr. Brigell is on the Editorial Board of Translational Vision Science and Technology and Documenta Ophthalmologica. Dr. Brigell received his Ph.D. in physiological psychology from Kansas State University and did his post-doctoral research in visual electrophysiology at Northeastern University, under the guidance of John Armington.

California Proposition 65 information

Prop-65Warning: This product can expose you to chemicals including lead, which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Substance Tables:

The table below lists substances which may be contained within LKC’s RETeval and RETevet products. Substances listed as Type 1 are within permissible levels in one or more of LKC’s products. Substances listed as Type 2 are used in the production of some components used in LKC products and may be present at trace levels, but are typically destroyed during processing. 

RETeval and RETevet Devices

Substance CAS # Type Listed as causing:
Nickel 7440-02-0 1 Cancer
Acrylonitrile 107-13-1 2
Ethylbenzine 100-41-4 2
Crystaline Silica 14808-60-7 1
Lead 7439-92-1 1 Cancer Developmental Toxicity Male Reproductive Toxicity Female Reproductive Toxicity
Methylene Chloride 75-09-2 2 Cancer Female Reproductive Toxicity
Bisphenol A 80-05-7 2
N-Hexane  110-54-3 2 Male Reproductive Toxicity